Bios: Genesis is a game about the origins of life on Earth, where players take on the role of organic compounds and strive to develop the first autocatalytic and Darwinian lifeforms. Players assign Bionts and Catalysts, roll dice for autocatalytic and Darwinian evolution, and purchase mutations and macroorganism upgrades. The game ends when the event deck runs out or Earth becomes uninhabitable, with the winner being the player with the most cubes and Bionts in their organisms.